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KMID : 0391419960060020117
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Korean Journal of Lipidology
1996 Volume.6 No. 2 p.117 ~ p.126
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Postprandial Triglyceride and Insulin Responses to a High Fat Meal in Healthy Premenopausal Women
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이종호
허갑범/신민정/윤지영/이양자/차봉수/김종희/공운영
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Abstract
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A remarkable inter-individual variability in postprandial serum triglyceride(TG) level is present even in subjects with same sex, similar age, body mass index and normal range of fasting cholesterol and triglycericde. As serum TG and insulin
levels
are
correlated and both seem to be associated with the insulin resistance syndrome, postprandial serum TG level may be related to postprandial insulin level. The purpose of this study was to determine the relationship of fasting and postprandial
serum
TG to
fasting and postprandial insulin levels.
After overnight fast, 77 healthy, premenopausal and non-obese women ingested a high fat sandwich, which contained 585 kcal consisting of 17% protein, 39% fat and 44% carbohydrate. Analysis of TG, insulin, free fatty acid(FFA), C-peptide, glucose,
HDL,
LDL and total cholesterol. At the next day, blood was obtained for measurement of glucose, insulin, C-peptide and FFA before, and 30, 60 120 min after, the 75g oral glucose road. Postprandial hjypertriglyceridemia or high responder was defined as
postprandial TG maxima above the 80th percentile(200mg/dL) of TG maxima distribution after a high fat meal in study subjects.
Fasting serum TG and TG max were highly correlated(r=0.872, p<0.00001). However, 9 of 16(56%) high responders had normal fasting serum TG(<150mg/dL.) therefore, we devided ihigh responders further into 2 group with normal and high fasting serum
TG(>150gm/dL). Although normal responders and high responders and high responders showed similar age and percent of ideal body weight, high responders with normal fasting serum TG showed the highest waist to hip ratio hip ratio and a remarkable
increase at 2, 3, 4, 5hr in the postprandial serum TG change. Postprandial serum FFA change at 1, 3, 6hr and postprandial insulin level at 1, 2, 6hr were higher in high responders with normal fasting TG, compared with normal responders and high
responders with high fasting TG, respectively. High responders with normal fasting serum TG showed the highest insulin response area during oral glucose tolerance tolerance test. TG max positively correlated with postprandial insulin area(r=0.32,
p<0.01) and insulin response area(r=0.40, p<0.005).
In healthy and non-obese women, the prediction of high response was only 44% based on fasting serum TG levels, Fifty six percents of high responders showed normal fasting serum TG levels, high magnitude and prolonged duration of postprandial TG
levels,
central type of body fat distribution and high postprandial insulin levels. Our results indicate that high postprandial serum TG responses in subjects with normal fasting TG levels, may link to the insulin resistance,
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KEYWORD
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